Vol. 3 No. 04 (2026): International Conference on Education and Innovation
Articles

2,5-DIMERKAPTO-1,3,4-TIADIAZOLNI GIDRAZINLI KOMPLEKSINI BIOLOGIK FAOLLIGINI IN SILICO USULLAR YORDAMIDA BAHOLASH

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  • Raxmatullayeva O.U,
  • Jaloliddinov F.Y,
  • Babayev B.N,
  • Kurbannazarova R.SH
Raxmatullayeva O.U
O‘zbekiston Milliy universiteti, Kimyo fakulteti, Tabiiy birikmalar va amaliy kimyo kafedrasi
Jaloliddinov F.Y
O‘zRFA akademik O.S. Sodiqov nomidagi Bioorganik kimyo instituti
Babayev B.N
O‘zbekiston Milliy universiteti, Kimyo fakulteti, Tabiiy birikmalar va amaliy kimyo kafedrasi
Kurbannazarova R.SH
O‘zbekiston Milliy universiteti, Biologiya fakulteti, biofizika kafedrasi

Published 04-05-2026

Keywords

  • 1,3,4-tiadiazol, molekulyar dokking, PASS Online, PTP1B, in silico, biologik faollik.
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

2,5-DIMERKAPTO-1,3,4-TIADIAZOLNI GIDRAZINLI KOMPLEKSINI BIOLOGIK FAOLLIGINI IN SILICO USULLAR YORDAMIDA BAHOLASH. (2026). INTERNATIONAL JOURNAL OF SCIENCE AND TECHNOLOGY, 3(04), 84-85. https://doi.org/10.70728/conf.edu.v3.i4.018

Abstract

Ushbu ishda 2,2’-((1,3,4-tiadiazol-2,5- diyil)bis(sulfandiyil)) di(atsetogidrazid) birikmasining biologik faolligi kompyuter modellashtirish usullari yordamida o‘rganildi. PASS Online natijalari moddaning serebral antiishemik va sitoprotektor xususiyatlarini ko‘rsatdi. Molekulyar dokking tahlillari PTP1B oqsili bilan yuqori bog‘lanish energiyasini (-7.7 kkal/mol) aniqladi, bu esa birikmaning diabetga qarshi potentsialini tasdiqlaydi.

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References

  1. 1. Filimonov D.A. et al. (2014). PASS Online: predicting biological activity spectra for chemical compounds. Bioinformatics.
  2. 2. Trott O., Olson A.J. (2010). AutoDock Vina: improving the speed and accuracy of docking. Journal of Computational Chemistry.
  3. 3. Jaloliddinov F.Y. va boshqalar. (2025). Tiadiazol hosilalarining sintezi va tahlili. O‘zMU xabarlari.